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A resubmission or renewal application should normally have the same title as the previous application or grant. But, if the specific aims of the project have docHubly changed, choose a new title that accurately describes the project.
Identify changes. Note: Identifying individual changes by using brackets, indents, or change of typography in the text of Specific Aims, Research Strategy, and other application attachments is no longer required, though NIH will continue to accept applications that contain the specific mark-ups.
Rules for Resubmitting Rule 1: You have just one opportunity to resubmit. Rule 2: You must apply within 37 months of the original applications receipt date. Rule 3: You must create a one-page introduction that addresses all your reviewers issues that are stated in your summary statement.
It is sufficient to outline the changes made to the resubmission application in the introduction attachment. The introduction must include a summary of substantial additions, deletions, and changes to the application. It must also include a response to the weaknesses raised in the Summary Statement.
A resubmission is an unfunded application that has been modified following initial review and resubmitted for consideration. A resubmission application can follow a competing new, renewal, or revision application (A0) that was not selected for funding (including applications not discussed in review).
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1. Can an additional Program Director/Principal Investigator (PD/PI) be added or removed before submitting a resubmission application? Yes, however, it is best to explain these changes in the introduction of your application. A change of PD/PI also needs to be noted via a checkbox in the application.
In 2014, NIH published an NIH Guide Notice on Modification to Guidance on Marking Changes in Resubmission Applications. The notice highlights that NIH has removed the requirement to identify substantial scientific changes in the text of a Resubmission application by bracketing, indenting, or change of typography.

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