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Data suggest that the aryl hydrocarbon receptor repressor might play a role of co-repressor on the transcriptional activity of the estrogen receptor alpha homodimer. These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers.
ATR plays a fundamental nuclear role in maintaining host genome integrity. RNAi-mediated inhibition of canonical ATR signaling suppresses genome replication. These our data suggest that ETAA1 is a new ATR activator involved in replication checkpoint control. ATR is a therapeutic target for synovial sarcoma treatment.
A hemolytic transfusion reaction is a serious complication that can occur after a blood transfusion. The reaction occurs when the red blood cells that were given during the transfusion are destroyed by the persons immune system. When red blood cells are destroyed, the process is called hemolysis.
Acute hemolytic transfusion reaction (AHTR) is a potentially fatal transfusion reaction and can be either due to immune or nonimmune mechanisms.
Acute hemolytic transfusion reactions (AHTRs) may occur when either incompatible red blood cells or large amounts of incompatible plasma are transfused.