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The high genetic diversity of HIV-1 allows its classification into groups, subtypes, subsubtypes, and circulating recombinant forms (CRFs).
Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approximately 50% of infections worldwide.
Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approximately 50% of infections worldwide. C-HIV is the predominant and near-exclusive subtype in the low resource regions of India and Southern Africa.
CRFs are recombinant HIV-1 genomes that share the same recombination breakpoints (BPs) between the same parentals and have been found in at least three non-epidemiologically related individuals. If a recombinant form does not fulfill the requirements to be considered a CRF, it is called a unique recombinant form (URF).
There are eight known HIV-2 groups, designated A to H. Of these, only groups A and B are pandemic. Group A is found mainly in West Africa, but has also spread to Angola, Mozambique, Brazil, India, Europe, and the US.
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Circulating recombinant forms (CRFs) are strains that have been observed in at least three epidemiologically unlinked individuals, whereas unique recombinant forms (URFs) have been observed in two individuals.

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