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Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an important first line of defence. IgA, also an important serum immunoglobulin, mediates a variety of protective functions through interaction with specific receptors and immune mediators.
Secretory IgA (SIgA) plays an important role in the protection and homeostatic regulation of intestinal, respiratory, and urogenital mucosal epithelia separating the outside environment from the inside of the body.
An antibody (Ab), also known as an immunoglobulin (Ig),[1] is a large, Y-shaped protein produced mainly by plasma (B-lymphocytes) cells that is used by the immune system to identify and neutralize pathogens such as bacteria and viruses.
These tests can check for autoimmune conditions in which the body mistakenly makes antibodies against healthy tissues, such as arthritis, lupus, and celiac disease. Kids born with low levels of IgA or none at all are at higher risk for autoimmune conditions, infections, asthma, and allergies.
IgD functions as a B cell antigen receptor and may participate in B cell maturation, maintenance, activation, and silencing. Although the exact function is still unclear, IgD may be involved in humoral immune responses by regulating B cell selection and homeostasis.
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IgD has delta heavy chains, and two subclasses, IgD1 and IgD2. Its biological role is unknown, but it may play a role as a surface receptor on lymphocytes. IgE has epsilon heavy chains. IgE is sometimes called a cytophilic antibody because it occurs on the membrane of mast cells or circulating basophilic granulocytes.
Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by infectious microorganisms. Such sites present a major site of susceptibility due to their vast surface area and their constant exposure to ingested and inhaled material.
IgA exists as two subclasses, IgA1 and IgA2, which differ both in their primary amino acid sequences and carbohydrate structures [2]. In serum, 7593% of IgA is IgA1, whereas in secretions the relative proportion of IgA1 is lower.

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