Human b6j form 2025

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The C57BL/6 (B6) mouse strain is the most widely used strain in biomedical research, with nearly 25,000 articles on Pubmed documenting its use. Nearly half of these articles cite the use of C57BL/6J (B6/J), the original B6 strain from the Jackson Laboratory (JAX) from which all other B6 substrains were derived.
C57BL/6, often referred to as C57 black 6, B6, C57 or black 6, is a common inbred strain of laboratory mouse. It is the most widely used genetic background for genetically modified mice for use as models of human disease.
C57BL/6 mice are also resistant to mouse cytomegalovirus through their expression of the LY49 receptor. These reports suggest that activation signals produced by NK cells may have an important role in the immune response differences between inbred strains.
In terms of aggression, the black 6 is about average. They are not the meanest mice, but not the most docile either. Males can be aggressive to each other after they reach puberty. Until recently researchers would prefer to use more female mice than males in their work due to their aggressive behavior.
Key characteristics of the C57BL/6 strain further enhance its utility in research settings. These mice have a notably high alcohol preference, making them an ideal model for studying alcoholism and addiction. They also exhibit specific auditory characteristics, including an early onset, high-frequency hearing loss.

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C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6J mice breed well, are long-lived, and have a low susceptibility to tumors.
Two substrains of this mouse strain, C57Bl/6J and C57Bl/6N, are in parallel widely used for research purposes. The two substrains are phenotypically identical but genetically differ by 34 SNPs, two indels and 15 gene variants that overlap a gene.
C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice.

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