Details of Application Changes - Enhancing Peer Review at NIH - enhancing-peer-review nih 2025

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A resubmission is an unfunded application that has been modified following initial review and resubmitted for consideration. A resubmission application can follow a competing new, renewal, or revision application (A0) that was not selected for funding (including applications not discussed in review).
The NIH peer review process forms the cornerstone of the NIH extramural research program. Through this process, NIH seeks to ensure that applications for funding receive fair, independent, expert, and timely scientific reviewsfree from inappropriate influencesso that NIH can fund the most promising research.
Example: If the award budget for total costs is $200,000, any rebudgeting that would result in an increase or decrease of more than $50,000 in a budget category is considered significant rebudgeting. Change in Scope A change in scope is an activity that requires both ISMMS and NIH prior approval.
Only approximately 15% of R01 and R01-equivalent grants are accepted for funding on the initial submission. However, this statistic increases to 30% if the appropriate steps are taken to revise and resubmit the grant.
Revision (Type 3). A request for an increase in support in a current budget period for expansion of the projects approved scope or research protocol. The request may specify budgetary changes required for the remainder of the project period as well as for the current budget period.
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Five core elements of peer review are identified. Constitutive elements of scholarly peer review include: fairness in critical analysis of manuscripts; the selection of appropriate reviewers with relevant expertise; identifiable, publicly accountable reviewers; timely reviews, and helpful critical commentary.
A renewal application competes with all other applications and must be fully developed as though the applicant is applying for the first time. Revision (Type 3). A request for an increase in support in a current budget period for expansion of the projects approved scope or research protocol.

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