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What is the rarest ANA pattern?

19.53%), cytoplasmic (n=78. 1.85%) and mitotic (n=80. 1.90%) were identified while mixed patterns constituted 9.70% (n=408). The most common ANA pattern was fine speckled (AC 4) with prevalence of 3.14% (n=132) whereas the rarest pattern was cytoplasmic fibrillar filamentous (AC 16) with prevalence of 0.02% (n=1).

What is the Euroimmun ANA profile 1?

The Euroimmun ANA Profile 1 is a semi-automated Immunoblot test for antibodies to12 ANA-related extractable nuclear antigens (ENAs). Traditional ENA profiles use a screening pool of 6 ENAs, with positive screening results followed by EIA testing for specific antibody to Sm, RNP, SS-A, SS-B, Scl-70, and Jo-1.

What is considered a high ANA number?

Because more than 30% of normal individuals have been found to have low ANA titers,5 the patients with negative or positive results at a titer of 1:40 were excluded. In our laboratory, an ANA titer of 1:640 is defined as a high titer because of a 0.5% prevalence of positives in normal individuals.

What is a positive ANA number for lupus?

The ANA test is used specifically for the diagnosis of systemic lupus erythematosis (SLE). A positive ANA titer ( 1:80) with the associated clinical signs (e.g. skin disease, polyarthritis) and laboratory findings (e.g. proteinuria, thrombocytopenia) is diagnostic for SLE.

What is ICAP nomenclature AC 8 9 10?

These patterns were recently defined by the International Consensus on ANA Patterns (ICAP) (2). Anti-nucleolar autoantibodies (ANoA) can be homogeneous (AC-8), clumpy (AC-9), or punctate (AC-10).

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