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There are three naloxone administration routes: Injected into the muscle (intramuscularly) Given through a vein (intravenously) Administered in the nose (intranasally)
In the event of a suspected opioid overdose, bystanders should call 911 and administer naloxone before any attempts at resuscitation (3-5).
Push half of the naloxone (1mL/1cc) into each nostril. The naloxone vial contains 2mL, so you are giving one half in one nostril and one half in the other nostril. Single-step nasal spray: Peel back tab with circle to open, insert tip into either nostril and administer full dose.
If you are the lone rescuer, perform rescue breathing and/or CPR for 2 minutes before leaving the victim to get help and supplies (naloxone, AED). Administer naloxone when available. In an out of hospital setting, naloxone can be administered via spray in the nose (2 mg) or with a needle into the arm (0.4 mg).
There are two options for BLS providers to administer Naloxone. One option is intranasal: administer 2 mg Naloxone using a mucosal atomizer device. The other option is intramuscular by autoinjector: administer 0.4 mg Naloxone using the autoinjector.
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