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Veronica from Michigan Medical School’s Office of Research explains the key aspects of cooperative agreement funding mechanisms, specifically NIH U-type grants. This video outlines the significant role of funding agency staff in these agreements and highlights best practices for applicants. Unlike typical grant funding mechanisms such as NIH R-type grants, cooperative agreements involve a higher level of engagement from funding agency staff in both scientific and administrative aspects. The primary purpose of these agreements is to support and encourage investigator-driven research. Veronica emphasizes the importance of understanding the unique characteristics of cooperative agreements before applying.