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the broadcast is now starting all attendees are in listen-only mode alright everybody we will go ahead and start in just about a minute so one more minute to let a few more people join us and then weamp;#39;ll go ahead and jump right in you all right everybody welcome to the May 2018 studies worldwide webinar today weamp;#39;re gonna be talking about design of experiments for pharmaceuticals with specifically active pharmaceutical ingredient development my name is Martin Besner Iamp;#39;m a statistician here at studies in Minneapolis so before I go any further I would just like to ask if you can hear me if you can click the raise hand button just so that I know that there isnamp;#39;t some technical problem here on my end so it looks like okay Allison okay so weamp;#39;ve got okay so it looks like um for those of you that canamp;#39;t hear me the the the problem probably isnamp;#39;t here so today we have quite a few attendees we have close to 50 people joining us here today oka