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In people, the incubation period (the time between initial contact with the virus and onset of the disease) generally ranges from two to eight weeks. In rare cases, it can vary from 10 days to 2 years. The incubation period is shorter in children and in people exposed to a large dose of the rabies virus.
Five general stages of rabies are recognized in humans: incubation, prodrome, acute neurologic period, coma, and death (or, very rarely, recovery) (Fig. 61-1). No specific antirabies agents are useful once clinical signs or symptoms develop.
You can't tell if an animal has rabies by just looking at it\u2014the only way to know for sure if an animal (or a person) has rabies is to perform laboratory testing. However, animals with rabies may act strangely. Some may be aggressive and try to bite you or other animals, or they may drool more than normal.
Tests are performed on samples of saliva, serum, spinal fluid, and skin biopsies of hair follicles at the nape of the neck. Saliva can be tested by virus isolation or reverse transcription followed by polymerase chain reaction (RT-PCR). Serum and spinal fluid are tested for antibodies to rabies virus.
The most widely used test for postmortem rabies diagnosis is the fluorescent antibody test (FAT), which is recommended by both World Health Organization (WHO) and World Organization for Animal Health (OIE). Developed by Goldwasser and Kissling in 1957, this test is still the gold standard for rabies diagnosis [20, 21].
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In people, the incubation period (the time between initial contact with the virus and onset of the disease) generally ranges from two to eight weeks. In rare cases, it can vary from 10 days to 2 years. The incubation period is shorter in children and in people exposed to a large dose of the rabies virus.
Clinical Manifestations Five general stages of rabies are recognized in humans: incubation, prodrome, acute neurologic period, coma, and death (or, very rarely, recovery) (Fig.
Doctors can diagnose rabies, but only by running several tests on your blood, skin, spinal fluid, and saliva.
Laboratory testing Rabies testing in animals is performed using a direct fluorescent antibody (DFA) to stain fresh brain tissue. Full cross sections of the brainstem and cerebellum are required for a valid test. The head of the animal should be refrigerated and shipped as soon as possible after death.
Rabies is a fatal infection, which usually progresses over 2 \u2013 21 days. A prodromal phase, lasting 2 \u2013 10 days, is characterized by pain and numbness/tingling at the site of the bite (present in 50% \u2013 80% of cases), and nonspecific complaints such as fatigue, headache and fever.

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