Rtog 1005 pdf-2025

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The document outlines the RTOG 1005 clinical trial, a Phase III study comparing accelerated whole breast irradiation with hypofractionation plus concurrent boost to standard whole breast irradiation with sequential boost for early-stage breast cancer patients. It details the study's objectives, eligibility criteria, treatment protocols, and statistical considerations. The trial aims to evaluate the efficacy and safety of a shorter radiation treatment schedule while maintaining local control of cancer and minimizing side effects. Key components include patient selection criteria, treatment plans, quality of life assessments, and data collection procedures.

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