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Definition. Substitution, as related to genomics, is a type of mutation in which one nucleotide is replaced by a different nucleotide. The term can also refer to the replacement of one amino acid in a protein with a different amino acid.
which types of mutations (positive, negative, neutral) are most likely to be seen in offspring several generations after the mutation occurred? neutral mutations and positive mutations will likely be seen in offspring because they don't hinder the likelihood of offspring from the mutated parent.
Genetic mutations which are inherited at birth are known as germline mutations; an example is sickle cell anaemia. Germline refers to mutations that occur in the sperm and egg. This genetic information is the source of all DNA for every cell in the body.
A genetic mutation is a change to a gene's DNA sequence to produce something different. It creates a permanent change to that gene's DNA sequence. Genetic variations are important for humans to evolve, which is the process of change over generations. A sporadic genetic mutation occurs in one person.
Deletion mutations, on the other hand, are opposite types of point mutations. They involve the removal of a base pair. Both of these mutations lead to the creation of the most dangerous type of point mutations of them all: the frameshift mutation.
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A genetic mutation is a change to a gene's DNA sequence to produce something different. It creates a permanent change to that gene's DNA sequence. Genetic variations are important for humans to evolve, which is the process of change over generations. A sporadic genetic mutation occurs in one person.
Two major categories of mutations are germline mutations and somatic mutations. Germline mutations occur in gametes, the sex cells, such as eggs and sperm. These mutations are especially significant because they can be transmitted to offspring and every cell in the offspring will have the mutations.
There are three types of DNA Mutations: base substitutions, deletions and insertions. Single base substitutions are called point mutations, recall the point mutation Glu -----> Val which causes sickle-cell disease.
A substitution mutation can cause the following: Change in the coding of amino acids codon to a particular stop codon resulting in an incomplete protein, which is usually non-functional. Can cause Silent mutations where a codon change can encode the same amino acid resulting in no changes in the protein synthesized.
Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.

choose a mutation from those in model 2