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Malignant hyperthermia is a life-threatening, but treatable reaction to certain anesthesia medications. It's caused by an inherited gene mutation (change) that affects your muscles. If you have a biological parent or relative who has the mutation, you're at greater risk for experiencing malignant hyperthermia.
Perioperative nurses should perform MH risk assessments during routine preoperative interviews to identify patients at risk for MH crisis. Perioperative nurses must respond rapidly and ensure the cooperation of the OR team when dealing with MH.
Placing a fan to blow directly on the patient while also spraying or sponging will increase the rate of evaporation, and thereby, will more rapidly decrease body temperature. Another option is to submerge a sheet in cold water and then wring it out, and then wrap the patient in the damp sheet.
Early signs of malignant hyperthermia Unexplained increase in heart rate (tachycardia). Unexplained increase in carbon dioxide produced by your body. Rapid breathing (tachypnea). Muscle rigidity. Rapid elevation in temperature.
Although the initial clinical signs of MH typically occur within one hour of anesthesia induction, the onset of MH can occur any time during the administration of triggering agents. The onset of MH in the postoperative period is extremely rare and does not generally manifest solely as temperature elevation.
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Males have a higher incidence than females, and patients less than the age of 50 are more likely to have MH. Pediatric patients are most frequently affected.
Treatments for malignant hyperthermia include the medication (, Revonto, Ryanodex), ice packs and other measures to cool body temperature, as well as supportive care.
The earliest signs are tachycardia, rise in end-expired carbon dioxide concentration despite increased minute ventilation, accompanied by muscle rigidity, especially following succinylcholine administration. Body temperature elevation is a dramatic but often late sign of MH.
It is triggered in susceptible individuals primarily by the volatile inhalational anesthetic agents and the muscle relaxant succinylcholine, though other drugs have also been implicated as potential triggers. MH is not an allergy but an inherited disorder that is found both in humans and in swine.
Provide hypothermia blankets or cooling blankets when necessary. Use cooling blankets that circulate water when the body temperature is needed to be cooled quickly. Set the temperature regulator to 1ºC below the client's current temperature to prevent shivering.

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