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AlloSure test is a non-invasive blood test designed to detect the presence of donor cell-free DNA in the recipients blood as a measure of the probability of rejection in heart transplant recipients. The result is displayed as a percent of donor-derived cell-free DNA (dd-cfDNA) in the totalcell-free DNA (cfDNA).
Using a threshold of 1%, the PPV for active rejection is 61% and the probability of rejection is much higher with the current result of 3.7%.
Change in AlloSure Results to Above Threshold Using a threshold of 1%, the PPV for active rejection is 61% and the probability of rejection is much higher with the current result of 3.7%.
The AlloSure test was introduced for routine use in kidney transplant recipients at Rush University Medical Center in October 2017, after CMS approval and then as part of the KOAR Study in May of 2018.
AlloSure is an assay designed to detect allograft rejection in kidney transplant recipients. According to the manufacturer of AlloSure (Care Dx, Inc), the test is intended to non- invasively measure donor DNA the blood for kidney transplant surveillance of active donor graft rejection.
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AlloSure test is a non-invasive blood test designed to detect the presence of donor cell-free DNA in the recipients blood as a measure of the probability of rejection in heart transplant recipients. The result is displayed as a percent of donor-derived cell-free DNA (dd-cfDNA) in the totalcell-free DNA (cfDNA).
AlloMap Kidney is a gene expression profile developed using candidate genes from the AlloMap assay broadly used in heart transplantation. AlloMap Kidney was validated to differentiate quiescence from rejection in two independent sample sets using a quantitative scale.
The AlloSure test was introduced for routine use in kidney transplant recipients at Rush University Medical Center in October 2017, after CMS approval and then as part of the KOAR Study in May of 2018.
Using a threshold of 1%, the PPV for active rejection is 61% and the probability of rejection is much higher with the current result of 3.7%.
With a dd-cfDNA cutoff value of 0.74%, AlloSure detected ABMR with 100% sensitivity, 71.8% specificity, 68.6% PPV, and 100% NPV.

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