Investigator database form 2025

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Even though 21 CFR part 56 does not mention the investigators brochure by name, much of the information contained in such brochures is clearly required to be reviewed by the IRB. The regulations do outline the criteria for IRB approval of research.
The applicant can submit a single completed Form FDA 3454 for all clinical investigators certifying to the absence of financial interests and append a list of those investigators to the form.
Form FDA 3500 may be used by health professionals or consumers for VOLUNTARY reporting of adverse events, product use/medication errors, product quality problems, and therapeutic failures for: Prescription and over-the-counter medicines including those administered in a hospital or outpatient infusion centers.
Requirements for Certification of Compliance with Certain Product Applications. FDA developed Form FDA 3674 which may be used to provide certification. The certification must accompany certain human drug, biological product and device applications and submissions.
The Form FDA 483 notifies the companys management of observed objectionable conditions. At the conclusion of an inspection, the Form FDA 483 is presented and discussed with the companys senior management.
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This regulation is intended to ensure that financial interests and arrangements of clinical investigators that could affect reliability of data submitted to FDA in support of product marketing are identified and disclosed by the sponsor of any drug, biological product, or device marketing application.
Form FDA 3454, or the Financial Certification or Disclosure Statement, is used to submit information regarding clinical investigators who participated in the clinical studies. If no clinical studies were performed, simply state: no clinical studies were performed to test this device.

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