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Is Naltrexone a Controlled Substance? The U.S. Drug Enforcement Administration (DEA) has not classified naltrexone as a controlled substance. However, it's currently available only through prescription by any healthcare practitioner licensed to dispense medications.
Naltrexone can be prescribed by any health care provider who is licensed to prescribe medications. To reduce the risk of precipitated withdrawal, patients are warned to abstain from illegal opioids and opioid medication for a minimum of 7-10 days before starting naltrexone.
Since naltrexone HCl is available in 50-mg tablets, low-dose naltrexone must be compounded for patients.
Naltrexone can be administered on a daily, twice a week or three times a week regimen, based on the clinical needs of the patient, and the therapeutic goals of the patient and therapist. Because naltrexone is unscheduled under the Controlled Substances Act, any licensed physician can prescribe this drug.
It comes in a pill form or as an injectable. The pill form of naltrexone (ReVia, Depade) can be taken at 50 mg once per day. The injectable extended-release form of the drug (Vivitrol) is administered at 380 mg intramuscular once a month.

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. . Ondansetron.
Naltrexone is not an opioid, is not addictive, and does not cause withdrawal symptoms with stop of use. Naltrexone blocks the euphoric and sedative effects of opioids such as heroin, morphine, and codeine. Naltrexone binds and blocks opioid receptors, and reduces and suppresses opioid cravings.
Yes, Naltrexone is a prescription drug. It is NOT a narcotic or a controlled substance, unlike other treatments for opioid use disorder (Methadone and Suboxone). However, it still requires a prescription from a medical professional.
The daily dosage can actually be over 100mg up to as high as 300mg. As the name implies, low dose naltrexone uses a much lower dose of this drug. The most common dosages are 1.5mg, 3mg, and 4.5mg. Patients may be titrated up or down based on how they respond to treatment.
Vivitrol, the brand name for naltrexone, is a narcotic blocker or what's known as an opioid antagonist. This medication, which is as effective as Suboxone, is a monthly injection. A potential downside for patients, though, is that it can only be administered after opioid withdrawal takes place.

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