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Radium is no longer used for cancer treatment. After World War II, it became possible to create man-made radioactive elements (radioisotopes) in nuclear reactors, instead of isolating radium from uranium ore.
On May 15, 2013, based on interim results from the ALSYMPCA trial, the FDA approved radium-223 for the treatment of men with castration-resistant prostate cancer with bone metastases that are causing symptoms.
Xofigo® (radium Ra 223 dichloride) injection is used to treat prostate cancer that no longer responds to hormonal or surgical treatment that lowers testosterone. It is for men whose prostate cancer has spread to the bone with symptoms but not to other parts of the body.
Xofigo is a medication used to treat prostate cancer that has spread to your bone. It can help prevent symptoms caused by the cancer in your bones. Xofigo is a radioactive targeted therapy. This means that it has 2 main parts: a radioactive part and a tumor-targeted part.
Bayer Receives U.S. FDA Approval for Xofigo® (radium Ra 223 dichloride) Injection as a New Treatment for Castration-Resistant Prostate Cancer with Bone Metastases. Bayer HealthCare Pharmaceuticals Inc.
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Xofigo treatment schedule Xofigo is given as 6 separate injections 4 weeks apart. Your last Xofigo injection will be 20 weeks (about 4 and a half months) after your first injection. You will come to MSK for each of your injections. You will also have a blood test 2 to 3 days before each injection.
Exposure to Radium over a period of many years may result in an increased risk of some types of cancer, particularly lung and bone cancer. Higher doses of Radium have been shown to cause effects on the blood (anemia), eyes (cataracts), teeth (broken teeth), and bones (reduced bone growth).
Xofigo Improves Bone Pain in Prostate Cancer Patients treated with Xofigo had a 34 percent reduction in the relative risk of any skeletal even compared with those in the placebo group. Patients in the Xofigo group experienced less overall bone pain than those in the placebo group.
Radium-223 Dichloride (also known as \u201cradium\u201d) is a radioactive material which is used to treat the spread of some cancers to the bones. Radium is normally given as a course of up to six intravenous injections, each given four weeks apart.
The most common side effects of Xofigo include: Nausea. Diarrhea. Vomiting. Swelling of the arms or legs (peripheral edema) Low blood cell counts.