FPIES Fact Sheet - The International FPIES Association - www2 aap 2025

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Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE mediated food allergy primarily affecting infants, characterized by severe gastrointestinal symptoms such as projectile vomiting and lethargy. It is often misdiagnosed and can mimic septic shock. Diagnosis relies on medical history and may require supervised oral food challenges, as standard allergy tests are typically negative. Common triggers include cow's milk and soy, with treatment focusing on avoidance of these foods and symptomatic management during acute episodes. Most children outgrow FPIES by age three.

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Is FPIES a disability?

FPIES is a type of food allergy, and food allergies are classified as disabilities protected by federal law.

Is FPIES genetic?

Most kids outgrow FPIES by 3 or 4 years old. Your provider might suggest a food challenge test if you want to reintroduce a trigger food. In the meantime, its important to figure out which foods are triggers and keep an eye on any reactions. Severe vomiting and diarrhea can be dangerous.

Is FPIES a rare disease?

FPIES is a severe type of food reaction. It is a rare disease primarily affecting infants and young children. (There are possible cases of FPIES in adults.)

What are the criteria for FPIES diagnosis?

Diagnostic criteria for acute FPIES The major criterion is vomiting 14 h after ingestion of a food with absence of IgE-mediated skin or respiratory symptoms.

What foods are most commonly linked to FPIES?

The most common FPIES food triggers are cows milk, soy, rice and oats, but any food can cause FPIES symptoms. Typical symptoms of FPIES include severe vomiting, diarrhea and dehydration two hours after eating.

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