Blue Guideline for Cholesterol Screening and Treatment of Hypercholesterolemia 2025

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The cholesterol test, or screening, requires a simple blood draw. The cholesterol test checks your levels of: Low-density lipoprotein (LDL) or bad cholesterol. Having high levels of LDL cholesterol can lead to plaque buildup in your arteries and result in heart disease or stroke.
There Is No Scientific Basis to Support Treating to LDL Targets. First, no major randomized clinical trial (RCT) has tested the benefits of treating patients according to LDL targets. The clinical trials tested fixed doses of drugs that lower lipid levels in specific patient populations.
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