Personality disorders and substance use 2025

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Borderline personality disorder (BPD) affects 2.7% of adults. About 78% of adults with BPD also develop a substance-related disorder or addiction at some time in their lives. These persons are more impulsive and clinically less stable than BPD patients without substance dependency.
Some personality changes are specific to certain substances. For example, using illicit stimulants could lead to restlessness, aggression, delusions or anxiety, and depression, while some opioid misuse could cause problems with attention, memory challenges, lack of awareness and coordination, or agitation.
Many people with BPD use substances to self-medicate, seeking relief from overwhelming emotions or aiming to feel dissociated. Social factors like peer pressure and negative interactions often drive substance use, which can lead to addiction.
Childhood trauma. One study found a link between the number and type of childhood traumas and the development of personality disorders. People with borderline personality disorder, for example, had especially high rates of childhood sexual trauma.
Some common serious mental disorders associated with chronic drug abuse include schizophrenia, bipolar disorder, manic depression, attention deficit hyperactivity disorder (ADHD), generalized anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, and antisocial personality
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Two specific PDs are particularly frequently diagnosed together with substance use problems: the borderline personality disorder (BPD) and the antisocial personality disorder (ASPD). Both disorders are associated with higher impulsivity and aggressive behavior (Walter, Wiesbeck, Dittmann, Graf, 2011).

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