Glucocorticoid-Induced Osteoporosis From the Bedside to the Bench and Back to the Bedside 2025

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ICD-Code M81. 4: Drug-induced osteoporosis.
Glucocorticoid-remediable aldosteronism E26. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Abstract. Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause docHub morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few months in a dose-dependent manner.
Glucocorticoids stimulate osteoclastogenesis and increase the expression of receptor activator of Nuclear factor-kappaB ligand and colony-stimulating factor-1, and decrease the expression of osteoprotegerin. However, the most docHub effect of glucocorticoids in bone is an inhibition of bone formation.
Sequencing for adverse-effect coding When osteoporosis is drug-induced, code the osteoporosis (M80. 4- / M81. 4) first, followed by T38. 0X5- with the appropriate 7th character (A, D, or S) to identify glucocorticoids as the causal drug.
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M85. 672 - Other cyst of bone, left ankle and foot | ICD-10-CM.
Bisphosphonates are currently the recommended first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis.
Glucocorticoid-Induced Osteoporosis (GIO) is a condition in which people who take medicines called glucocorticoids develop osteoporosis, which means weakening of the bones.

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