Current Methods for the Detection of Antibodies of Varicella 2025

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An MMR immunity test, also known as an MMR titer test or MMR immunity blood work, can determine whether you have developed antibodies against measles, mumps and rubella, three common and highly contagious viral diseases.
Whole infected cell (wc) ELISA is the most commonly used test to determine if a person has antibodies to VZV from past varicella disease. Wc ELISA taken from blood samples can readily detect seroconversion to natural infection with VZV.
A varicella titer, also called a varicella antibody titer test or VZV titer, is a blood test to check for your immunity to chickenpox due to previous vaccination or infection. It checks for chickenpox antibodies (concentrations of IgG antibodies) in the blood.
Evidence of immunity to varicella includes any of the following: Documentation of age-appropriate varicella vaccination. Laboratory evidence of immunity or laboratory confirmation of disease.
You will need to provide a sample of blood from your vein or from the fluid in one of your blisters. Blood tests check for antibodies to the VZV. Blister tests check for the virus itself. For a blood test from a vein, a health care professional will take a blood sample from a vein in your arm using a small needle.
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However, if you cant remember whether or not youve already been infected with chickenpox, you can ask your GP. Your GP may have noted in your medical records that you have previously been infected with chickenpox. If this information was not recorded, then your GP can check if you have immunity with a blood test.
Indirect immunoenzyme assay to test antibodies against varicella-zoster virus in human serum/plasma. The ELISA method is based upon the reaction of antibodies in the sample tested with the antigen adsorbed on the polystyrene surface. Unbound immunoglobulins are washed off.

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