Reach and Validity of An Objective Medication Adherence Measure 2025

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Medication Adherence Questionnaire (MAQ) The MAQ is also known as the 4-item Morisky Medication Adherence Scale (MMAS-4) and Morisky Scale [4, 38, 44, 49]. This questionnaire is the quickest to administer and score and is only able to identify barriers to adherence due to its length [4].
The five dimensions are patient-related factors, medication-related factors, condition-related factors, healthcare system/healthcare provider (HCP)-related factors, and socioeconomic factors.
Direct observation of therapy The patient act of consuming the recommended medication is observed by an external observer like a family member or a trained provider. It can be considered as the closest to the gold standard for assessing medication adherence.
The five‐item Medication Adherence Report Scale (MARS‐5) shows promise as an effective tool for assessing adherence, identifying patients reporting low adherence and the specific types of nonadherence behaviours (eg, forgetting, deliberately missing doses).
The Brief Adherence Rating Scale (BARS) is a 4-item, clinician-administered rating scale that captures a patients intake of the antipsychotic medications.
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In prospective medication adherence studies, researchers can utilize objective and subjective methods to observe medication adherence. Such methods include direct observation, pill counts, therapeutic drug monitoring, and devices that measure when and how medications have been ingested or used.
The MARS-5 questionnaire consists of five questions on forgetting, changing dosage, stopping, skipping, and taking less medication (Table 3). The score ranges from 5 to 25, where a higher MARS-5 score indicates higher self-reported adherence.
Adherence Score, also known as the Days with Medication or Medication Possession Ratio (MPR), is the industry measure of medication adherence. A patients overall adherence score is the average adherence score of all their active chronic medications.

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