From Gene to Protein Transcription and Translation - Serendip 2025

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During transcription, the enzyme RNA polymerase (green) uses DNA as a template to produce a pre-mRNA transcript (pink). The pre-mRNA is processed to form a mature mRNA molecule that can be translated to build the protein molecule (polypeptide) encoded by the original gene.
The journey from gene to protein is complex and tightly controlled within each cell. It consists of two major steps: transcription and translation. Together, transcription and translation are known as gene expression.
Starting in the nucleus, we see how the DNA code is converted to messenger RNA by the process of transcription. We then follow the messenger RNA into the cytoplasm where it is bound by protein factories, called ries. The ries read the messenger RNA to produce a chain of amino acids.
In this article, well address how gene expression leads to protein synthesis, going through all these different steps. Step 1: Transcription: DNA to mRNA. Step 2: mRNA Processing. Step 3: Translation: mRNA to protein. Step 4: Post-Translational Modifications (PTMs) Step 5: Visualisation of gene expression.
Published online: July 8, 2022. Protein synthesis in eukaryotes is carried out by 80S ries with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and rie recycling.
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In order for a cell to manufacture these proteins, specific genes within its DNA must first be transcribed into molecules of mRNA; then, these transcripts must be translated into chains of amino acids, which later fold into fully functional proteins.
Summary of the different steps for protein synthesis and gene expression: Step 1: Transcription: DNA to mRNA. Step 2: mRNA Processing. Step 3: Translation: mRNA to protein. Step 4: Post-Translational Modifications (PTMs) Step 5: Visualisation of gene expression. Step 6: Regulation of gene expression.

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