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When is preimplantation genetic diagnosis acceptable? - Brandeis

When is preimplantation genetic diagnosis acceptable? - Brandeis 2025

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The document is a Master's thesis by Kathryn A. Charyk, presented to Brandeis University, exploring the attitudes of university students towards preimplantation genetic diagnosis (PGD). It examines the moral acceptability, legal status, insurance coverage, and personal use of PGD in various scenarios. The study finds that students generally view PGD as morally acceptable for medical reasons but not for nonmedical uses like sex selection or positive selection for deafness. The research highlights the lack of consensus on PGD's applications and suggests that personal beliefs significantly influence opinions on its acceptability.

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For what disorders can a preimplantation genetic diagnosis be offered?

This technique examines embryos using either cytogenetic or molecular techniques for (1) single-gene disorders (eg, Huntington disease, cystic fibrosis, fragile X syndrome), including those that are autosomal dominant and recessive or X-linked, or (2) hereditary cancer syndromes (eg, hereditary and ovarian

Who is eligible for preimplantation genetic diagnosis?

One of the main limitations of PGT-M is the genetic variability and complexity inherent to monogenic diseases themselves. Hereditary genetic diseases can be caused by different mutations on the same gene or mutations on different genes that lead to similar phenotypes.

Who can get PGD?

PGD is available for almost any inherited condition for which the exact mutation is known. A unique test must be developed for each couple, however. This test design may take up to several months to complete before beginning an IVF cycle. PGD uses IVF, in which multiple eggs are matured and retrieved.

Under which condition can preimplantation genetic testing be performed?

Doctors also recommend that women who are considered to be at advanced maternal age (35 and older) use PGD. This is because as a woman gets older, the chromosomes in her eggs do not always divide normally, which can increase the chance of developing embryos with abnormal chromosomes.

At what stage of development is preimplantation diagnosis used?

The two main steps to the three types of PGT are the same. The first step is an embryo biopsy. The second step is analysis of the biopsy by a laboratory to conduct genetic testing on DNA. In both forms of testing, the biopsy is at the blastocyst (day 5 or day 6 of embryo culture) stage of development.