Early bell stage: Topics by Science 2025

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EpithelialMesenchymal Interactions Regulating Dentin and Enamel Formation. Dentin and enamel are mineralized tissues produced at the late bell stage of tooth development by tooth-specific cells: the mesenchyme-derived odontoblasts that produce dentin and the epithelial ameloblasts that produce enamel.
The stellate reticulum was believed to function as a spacer device for mechanical protection for tooth crown formation and for nutritional recruitment from the outlying vascular circulation to stellate reticulum cells [64].
The dental organ (B through D), in the cap stage, consists of inner dental epithelium, IDE, (B) which forms the inner lining of the cap, outer dental epithelium, ODE, (C) which forms the outer lining of the cap, and the stellate reticulum (D) occupying the area between the two epithelial layers.
At the bell stage of tooth development, the dental follicle, or dental sac, is clearly divided into three layers the inner layer adjacent to the outer surface of enamel organ and dental papilla, the outer layer adjacent to the developing alveolar bone, and a less densely populated intermediate layer separating the
The bell stage is known for the histodifferentiation and morphodifferentiation that takes place. The dental organ is bell-shaped during this stage, and the majority of its cells are called stellate reticulum because of their star-shaped appearance. The bell stage is divided into the early bell stage and the late bell .
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Characteristic features of bell stage: The columnar cells of the enamel organ adjacent to the enamel papilla are known as inner enamel epithelium (IEE). The cells between the IEE and the stellate reticulum(SR) form a layer known as the stratum intermedium(SI).
Bell stage: At this stage, the dental lamina disintegrates and is ready for the formation of dental hard tissue. Dentine formation (Dentinogenesis): Cells from the inner enamel epithelium induce the cells at the periphery of the dental papilla to form dentin forming columnar cells i.e., odontoblasts.
Tooth development is commonly divided into the following stages: the initiation stage, the bud stage, the cap stage, the bell stage, and finally maturation.

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