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Subgroup analyses involve splitting all the participant data into subgroups, often so as to make comparisons between them. Subgroup analyses may be done for subsets of participants (such as males and females), or for subsets of studies (such as different geographical locations).
WHAT ARE SUBGROUP ANALYSES? In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint (e.g., overall survival) in subgroups of patients defined by baseline characteristics (e.g., age, gender, histology, and ethnicity).
Statistical regression models are commonly used to test for treatment-by-subgroup interactions. The independent variables in these models include the main treatment effect, the variable defining the subgroups, and the treatment-by-subgroup interaction terms.
For instance, in a clinical trial studying a new diabetes medication, a subgroup analysis might reveal that the medication works better in adults over the age of 50 than in younger participants.
Types of subgroup analysis Pre-specified Subgroup Analysis. Post-hoc Subgroup Analysis. Benefits of Subgroup Analysis:

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As above, stratification is different from subgroups in two aspects: (a) in a single study, grouped indicators are generally interventions that must be pre-set, whereas stratified indicators are often considered potential confounding variables; (b) in a meta-analysis, an included study is considered a unit and assigned
We therefore provide 5 criteria to use when assessing the validity of subgroup analyses: (1) Can chance explain the apparent subgroup effect; (2) Is the effect consistent across studies; (3) Was the subgroup hypothesis one of a small number of hypotheses developed a priori with direction specified; (4) Is there strong
A subgroup of a group G is a subset of G that forms a group with the same law of composition. For example, the even numbers form a subgroup of the group of integers with group law of addition. Any group G has at least two subgroups: the trivial subgroup {1} and G itself.
Subgroup analyses examine findings in categories of subjects in the sample. Sensitivity analyses examine whether the findings remain similar if the data are handled in a way that differs from the original plan of analysis. Post hoc analyses examine hypotheses that are conceptualized after the data are seen.

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