What is lysozyme and why is it used in Winemaking? 2025

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Lysozyme is presented as a natural preservative in mammalian milk and can be utilized as a bio-preservative in dairy products, such as cheese. Both bacteria and fungi can contaminate and spoil the cheese; especially the one that is made traditionally by raw milk.
Lysozyme is an important part of the innate immune system and exhibits strong antimicrobial activities against bacterial, fungal, and viral pathogens. It protects against infections, acts as a natural antibiotic, and enhances the efficacy of other antibiotics, while it also strengthens the immune system [4].
The LYSOZYME is efficient destroying the vegetative bacteria of Clostridia and specifically of Clostridium tyrobutyricum. These bacteria are capable of surviving the normal thermal treatment used in milk for making cheese and they can later spread causing the late blowing.
Pectic Enzymes are the most beneficial and most commonly used enzyme class for winemaking. Currently available pectic enzymes may have fairly specific functions, but alternatively, may be formulated to perform multiple functions.
The use of lysozyme during the preparation of cheeses and wines is particularly effective in reducing the numbers of bacteria. Lysozyme is an enzyme that targets the cell walls of certain bacteria by breaking down a component known as peptidoglycan.
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Lysozyme is used by winemakers to control the growth of gram-positive spoilage bacteria, to control certain aspects of malolactic fermentations, and to stabilize wines after alcoholic fermentation or when malolactic fermentation is completed.
In winemaking, lysozyme is used for the control of lactic acid bacteria, and it is considered essential to obtain consistent and high quality. Lysozyme can be used at different stages of wine production and at different doses, and no steps are taken specifically to remove lysozyme from wine.

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