Medications in Pregnant and 2025

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Valproate is approved by the U.S. Food and Drug Administration (FDA) for acute manic or mixed episodes and is widely used off label for prophylaxis. However, valproate should be avoided if possible during pregnancy because of an association with increased rates of congenital malformations and neurodevelopmental delays.
TABLE 3. DrugComments Chloramphenicol Gray Baby Syndrome[7]. Ciprofloxacin Possibility of joint abnormalities (seen in animals)[7] Kanamycin and Streptomycin Damage to fetuss ear resulting in deafness (risk of ototoxicity)[7] Sulfonamides Jaundice and brain damage in newborn[7]28 more rows
Some medications are dangerous to take during pregnancy. They can cause birth defects or raise your risk of miscarriage. These include retinoids, warfarin, and certain blood pressure medications. NSAIDs, certain antibiotics, and benzodiazepines can also harm a growing baby.
Fluoroquinolones. Fluoroquinolone antibiotics include ciprofloxacin (Cipro), levofloxacin, and moxifloxacin. They arent often used in pregnancy because they have a risk of causing birth defects. Fluoroquinolones may cause harm to a fetus developing heart, kidneys, or brain.
The most commonly used medications include antiemetics, antacids, antihistamines, analgesics, antimicrobials, diuretics, antidepressants, and tranquilizers. Substance use and misuse is also common. Despite this trend, firm evidence-based guidelines for safe use of medications during pregnancy are still lacking. Drug Safety in Pregnancy - Gynecology and Obstetrics merckmanuals.com professional drug-sa merckmanuals.com professional drug-sa
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Teratogenic drugs and medicines ACE (angiotensin converting enzyme) inhibitors used to treat high blood pressure or congestive heart failure. Angiotensin II antagonists, also used to treat high blood pressure or congestive heart failure. Isotretinoin (an acne drug) Alcohol. . high doses of vitamin A. Lithium.
Category A: No risk in human studies (studies in pregnant women have not demonstrated a risk to the fetus during the first trimester). Category B: No risk in animal studies (there are no adequate studies in humans, but animal studies did not demonstrate a risk to the fetus). Category C: Risk cannot be ruled out.

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