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Registration of Research with RDNA doc

Registration of Research with RDNA doc 2025

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The document outlines the registration process for research involving recombinant DNA at Johns Hopkins University, detailing necessary information for compliance with NIH guidelines. It includes sections on biosafety levels, types of materials used, and specific requirements for various experiments involving infectious agents, human tissues, and toxins. The form must be completed by the principal investigator and includes a summary of the research project, risk assessments, and safety practices to ensure safe handling of recombinant materials.

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What incidents must be reported to NIH?

These kinds of events might include skin punctures with needles containing recombinant DNA, the escape or improper disposition of a transgenic animal, or spills of high-risk recombinant materials occurring outside of a biosafety cabinet.

What should an institutional biosafety committee include in the annual report to the NIH OSP?

The institution must file an annual report that includes: An updated committee roster indicating the role of each committee member (e.g., chairperson, contact person, non-institutional members, special experts as relevant, etc.), and. Biosketches for each new member on the committee.

What is the protocol for recombinant DNA?

The steps in recombinant DNA technology include: isolating DNA from the donor and host organisms, cutting the DNA using restriction enzymes, joining the fragments with DNA ligase, introducing the recombinant DNA into the host organism, and selecting and screening transformed cells.

What kind of incident should be reported?

Various incidents are reported, including workplace injuries, accidents and near-misses, data breaches and security threats, medical emergencies, and customer complaints. Each one needs to be properly documented so incidents can be tracked over time and patterns can be identified.

What is rDNA research?

Recombinant DNA technology involves using enzymes and various laboratory techniques to manipulate and isolate DNA segments of interest. This method can be used to combine (or splice) DNA from different species or to create genes with new functions.

Which of the following incidents involving rDNA should be reported to NIH?

Researchers are responsible for immediately reporting any spill and/or accident involving recombinant or synthetic nucleic acid molecules research resulting in an overt or possible exposure, or that otherwise could lead to personal injury or illness, or to a breach of containment to their PI, the Biosafety Officer (BSO

What is the penalty for performing rDNA work without approval?

Non-compliance may result in Suspension, limitation, or termination of financial assistance for the noncompliant NIH-funded research project and of NIH funds for other rDNA research at NAU, or The requirement for prior NIH approval of any and/or all rDNA projects at NAU.

Registration of Research with RDNA doc 2025

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