Update on the Treatment of Major Depressive Disorder 2025

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The basic principle behind the headset transcranial direct current stimulation (tDCS) is increasingly supported by research, however. The working theory behind tDCS is that sending a mild (and painless) electric current into the brain can stimulate areas that are less active in people with depression.
Transcranial Magnetic Stimulation (TMS) is a procedure where magnetic fields are used to generate an electric stimulus (much lower than ECT) that stimulates cells in the brain to improve symptoms associated with depression. TMS can also be called rTMS, with the r referring to the repetitive magnetic pulses.
Esketamine: new therapy for severe depression The findings from limited clinical trials indicate that intranasal esketamine is effective and safe in patients with TRD, although the optimum dose, duration and frequency of use are not fully understood.
Titusville, New Jersey, January 21, 2025 Johnson Johnson (NYSE: JNJ) announced today the U.S. Food and Drug Administration (FDA) approval of a supplemental New Drug Application (sNDA) for SPRAVATO (esketamine) CIII nasal spray, making this innovative treatment the first and only monotherapy for adults living with
Ketamine has been used in medical settings for years. But SPRAVATO is the first FDA-approved treatment specifically for treatment-resistant depression (TRD) or depressive symptoms in adults with major depressive disorder (MDD) accompanied by suicidal thoughts or actions..
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Electroconvulsive Therapy ECT is the established best therapeutic option for TRD, but its neurophysiological mechanism of action is yet to be elucidated. In the treatment of TRD, ECT is applied 23 times per week and acute courses can range between 618 total sessions.

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