The Contamination Control Challenge Cleaning and Disinfection 2025

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Control measures are procedures and practices designed to eliminate or reduce contamination risks. These can include: Environmental monitoring: Regular monitoring of air, surfaces, and personnel to track contamination levels.
The aim of all contamination control activities is to permanently ensure a sufficient level of cleanliness in controlled environments. This is accomplished by maintaining, reducing, or eradicating viable and non-viable contamination for either sanitary purposes or in order to maintain an efficient rate of production.
Monitoring environmental parameters is fundamental to contamination control. This includes regular testing for microbial and particulate levels in the air, on surfaces, and on personnel. Automated environmental monitoring systems can capture real-time data, improving responsiveness and compliance.
The boundary between the Support Zone and the CRZ is called the Contamination Control Line. This separates the low contamination area from the clean Support Zone.
A Contamination Control Strategy (CCS) should be implemented across the facility in order to define all critical control points and to assess the effectiveness of all the controls (design, procedural, technical and organisational) and monitoring measures employed to manage risks to medicinal product quality and safety.
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There are four main types of contamination: chemical, microbial, physical, and allergenic.
A Contamination Control Strategy (CCS) is a systematic approach designed to minimize contamination risks across various environments, particularly in biotechnology, food production, healthcare and pharmaceutical manufacturing industries.

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