Home
Forms Library
Antisynthetase syndrome

Antisynthetase syndrome 2025

Antisynthetase syndrome Preview on Page 1

Show details

4.9 out of 5

21 votes

The document discusses Antisynthetase syndrome, a rare chronic autoimmune disease characterized by the presence of autoantibodies against aminoacyl-tRNA synthetases. It is a subgroup of idiopathic inflammatory muscle diseases, primarily presenting with myositis, interstitial lung disease, and arthritis. The etiology remains unknown, and the prevalence is not well established. Treatment typically involves corticosteroids and immunosuppressive agents, although their efficacy lacks robust clinical trial support. The document outlines clinical features, laboratory evaluations, differential diagnoses, and prognosis.

Here's how it works

01. Edit your form online

Type text, add images, blackout confidential details, add comments, highlights and more.

02. Sign it in a few clicks

Draw your signature, type it, upload its image, or use your mobile device as a signature pad.

03. Share your form with others

Send it via email, link, or fax. You can also download it, export it or print it out.

The fastest way to redact Antisynthetase syndrome online

Ease of Setup

DocHub User Ratings on G2

Ease of Use

DocHub User Ratings on G2

Dochub is the best editor for modifying your documents online. Follow this straightforward guideline redact Antisynthetase syndrome in PDF format online free of charge:

Register and sign in. Register for a free account, set a strong password, and go through email verification to start managing your templates.
Upload a document. Click on New Document and choose the file importing option: upload Antisynthetase syndrome from your device, the cloud, or a secure URL.
Make changes to the sample. Utilize the upper and left panel tools to edit Antisynthetase syndrome. Insert and customize text, images, and fillable areas, whiteout unneeded details, highlight the important ones, and comment on your updates.
Get your paperwork accomplished. Send the sample to other individuals via email, generate a link for faster file sharing, export the sample to the cloud, or save it on your device in the current version or with Audit Trail added.

Explore all the advantages of our editor today!

be ready to get more

Complete this form in 5 minutes or less

Get form

Got questions?

We have answers to the most popular questions from our customers. If you can't find an answer to your question, please contact us.

What is the life expectancy of someone with antisynthetase syndrome?

In fact, life expectancy is curtailed in aSS and the major cause of death is ILD and pulmonary hypertension. The 5-year survival is 90% in anti-Jo-1-positive patients and 75% in non-Jo-1-positive patients but the 5-year survival can be as low as 31%.

What is the age of onset for antisynthetase syndrome?

Antisynthetase syndrome is 23 times more common in women than in men. The age at onset among adults ranges from 19 to 82 years with a mean age at onset varying from 43 to 60 yrs.

What are the criteria for antisynthetase syndrome?

Anti-synthetase syndrome is an autoimmune disease characterized by autoantibodies against one of many aminoacyl transfer RNA (tRNA) synthetases with clinical features that may include interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynauds phenomenon, unexplained fever and/or mechanics hands (1).

What is the triad of antisynthetase syndrome?

Anti-Jo-1 is the most common antisynthetase antibody and is the most likely to present with the classic triad of myositis, ILD, and arthritis. Patients with anti-Jo-1 antibodies have more muscle and in particular more joint involvement than patients with other antisynthetase antibodies [17].

How serious is antisynthetase syndrome?

Antisynthetase syndrome usually isnt fatal. People living with it dont usually have a different life expectancy than usual. Most people live with it for the rest of their lives but can manage their symptoms with treatments.

What are the markers for antisynthetase syndrome?

The hallmark of antisynthetase syndrome is the presence of serum autoantibodies directed against aminoacyl-tRNA synthetases. These are cellular enzymes involved in protein synthesis. Antisynthetase antibodies include Jo-1, PL-7, PL-12, OJ, EJ, KS, Wa, YRS, and Zo.

What triggers antisynthetase syndrome?

What Causes Antisynthetase Syndrome? The exact cause is unknown, but researchers have linked it to the production of a specific autoantibody, called Anti-Jo-1, that attacks healthy tissue because the patients immune system is overactive. Its more common in women than men, and the average age of onset is 50.

Antisynthetase syndrome 2025

Here's how it works