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Unstable Microsatellites and Human Disease Advance Registration

Unstable Microsatellites and Human Disease Advance Registration 2025

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The document is an advance registration form for the 5th International Conference on Unstable Microsatellites and Human Disease, taking place in Granada, Spain from November 11-16, 2006. It outlines registration details, fees, accommodations, included meals and events, a guided tour of The Alhambra, payment methods, and cancellation policies.

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What is the disease caused by expanded microsatellite repeats?

An expanded repeat located in a non-coding region causes cellular toxicity in myotonic dystrophy (DM), fragile X-associated tremor/ataxia syndrome (FXTAS) and spinocerebellar ataxias type 8, 10 and 12 (SCA8, SCA10 and SCA12).

Are microsatellites repetitive DNA?

Because microsatellites consist of such repetitive sequences, DNA polymerase may make errors at a higher rate in these sequence regions. Several studies have found evidence that slippage is the cause of microsatellite mutations. Typically, slippage in each microsatellite occurs about once per 1,000 generations.

What diseases are caused by microsatellites?

More than 50 neurological diseases are caused by microsatellite repeat expansions, including myotonic dystrophy, C9ORF72 amyotrophic lateral sclerosis/ frontotemporal dementia (C9-ALS/FTD), and Huntington disease (HD).

What is the most common microsatellite in humans?

The most common microsatellite motifs in the human genome are A/T rich and more than a third of microsatellites in our data set (36.4%) are composed of the motifs A/T or AC/GT (Table 1).

Which of the following disease in humans is caused due to expanded microsatellite repeats?

Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2), Huntingtons disease, and C9orf72-linked amyotrophic lateral sclerosis (C9-ALS).