PEDIATRIC and ADOLESCENT OSTEOSARCOMA 2025

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About half of these are in children and teens. Most osteosarcomas occur in children, teens, and young adults between the ages of 10 and 30. Teens are the most commonly affected age group, but people of any age can develop osteosarcoma. About 1 in 10 osteosarcomas occur in people older than 60.
5-year relative survival rates for osteosarcoma SEER* stage5-year relative survival rate Localized 76% Regional 64% Distant 24% All SEER stages combined 59%
Doctors often use the observed survival rate when they talk about a prognosis. The 5-year observed survival for osteosarcoma in children 0 to 14 years of age is 65%. This means that, on average, 65% of children diagnosed with osteosarcoma are expected to live for at least 5 years after their diagnosis.
Most people with osteosarcoma dont have any known risk factors for the cancer. But these factors can increase the risk of osteosarcoma: Certain conditions that run in families. These include hereditary retinoblastoma, Bloom syndrome, Li-Fraumeni syndrome, Rothmund-Thomson syndrome and Werner syndrome.
Osteosarcoma is cancer that begins in your bones, usually in the arms or legs. Limited movement, bone pain, a lump and an unexplained broken bone are the most common symptoms. Many treatments are available. Around 7 in 10 people survive if the osteosarcoma doesnt spread to other parts of their bodies.
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There are a few risk factors that have been associated with osteosarcoma. Children who have hereditary retinoblastoma (a rare tumour of the eye) have an increased risk of developing osteosarcoma. Children who have previously had radiotherapy and chemotherapy also have an increased risk of developing osteosarcoma.
Most childhood cancers are caused by DNA changes (mutations) that happen early in the childs life, sometimes even before birth. Because of this, there are not many known risk factors or ways to prevent childhood cancers.

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