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25-27 Antibiotic prophylaxis should be given 30-60 minutes prior to the procedure; however, it can be given up to two hours after a dental procedure. 6 A different class of antibiotics is indicated if the patient is already on oral antibiotic therapy or has an allergy or anaphylactic reaction.
Broad-spectrum antibiotics target many types of bacteria. Both types work well to treat infections. But using broad-spectrum antibiotics when theyre not needed can create antibiotic-resistant bacteria that are hard to treat. They may also have side effects, such as diarrhea or rash.
[1] The routine administration of prophylactic antibiotics is standard in cases where a patient will have an artificial implant or foreign body implanted as part of the procedure, bone grafting procedures, and other surgeries with extensive dissections or expected high blood loss.
Prophylaxis is recommended for the patients identified in the previous section for all dental procedures that involve manipulation of gingival tissue or the periapical region of the teeth, or perforation of the oral mucosa. Procedures requiring prophylaxis include: Dental Cleaning. Tooth extractions.
Situations where antibiotics are given as a preventive treatment include: if youre having an operation. after a bite or wound that could get infected. if you have a health problem that means youre at higher risk of infection, such as if youve had your spleen removed or youre having chemotherapy treatment.

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For surgical procedures, intravenous prophylactic antibiotics should be given within 60 minutes before the skin is incised and as close to time of incision as practically possible. therefore, the administration of these agents should begin within 120 minutes before surgical incision.
In addition to treating infection, antibiotics are for a prophylactic purpose, including the prevention of clinically relevant infection in people undergoing surgery, invasive operations, and cancer chemotherapy as well as those with other conditions that put people at high risk5.

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