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Registration of Hazardous Microbial and Recombinant DNA Research

Registration of Hazardous Microbial and Recombinant DNA Research 2025

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The document outlines the procedures and requirements for conducting research involving hazardous biological agents and recombinant DNA at The University of Texas at Brownsville. It includes sections for application details, project summaries, safety protocols, and compliance with NIH guidelines. The document emphasizes the need for Institutional Biosafety Committee (IBC) approval, risk assessment, and adherence to safety regulations regarding human subjects, animal use, and potential dual-use concerns.

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What is the purpose of an IBC?

An intermediate bulk container (or IBC) is a pallet mounted, industrial grade reusable container that is used for storing and transporting bulk liquids and powders. Also known as a tote, the IBC is capable of stacking and can be moved by a pallet jack or forklift.

What are the safety considerations for recombinant DNA?

Laboratory coats should be worn in the laboratory whenever rDNA work is being done. Do not wear these coats into areas in which food or drink may be consumed. Isolate them in a plastic bag when taking them to the laundry. Disposable gloves must be worn when handling microorganisms or nucleic acids.

What is an IBC research?

Institutional Biosafety Committee (IBC). This U-M entity is responsible for the biological safety review and approval of the research use of recombinant DNA, synthectic nucleic acid molecules, infectious agents, biological toxins, federally-regulated select agents, and more.

What research must be registered with the UMD Institutional Biosafety committee?

You must register your research with the IBC if it involves any of the following: recombinant or synthetic nucleic acid molecules as described by the NIH Guidelines, human materials such as blood, cells, or tissue, infectious agents, or potentially pathogenic material.

Who makes the initial risk assessment for rDNA research?

1 In order to establish appropriate safeguards for activities with recombinant DNA, the investigator will make an initial risk assessment based on the Risk Group (RG) of an agent (see Appendix B, of the NIH Guidelines: Classification of Human Etiologic Agents on the Basis of Hazard).

What is the difference between IRB and IBC?

In a nutshell: IRBs are concerned with risks to human research subjects, and IBCs are concerned with risks to anyone who might come in contact with a studys genetically modified material.

What does IBC stand for in science?

In ance with the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules, the National Institute of Environmental Health Sciences (NIEHS) has established an Institutional Biosafety Committee (IBC).

Registration of Hazardous Microbial and Recombinant DNA Research 2025

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