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CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE - cdc

CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE - cdc 2025

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The document outlines a public health response plan for addressing cephalosporin-resistant Neisseria gonorrhoeae (Ceph-R NG) in the United States. It highlights the increasing threat of antimicrobial resistance in gonorrhea treatment, emphasizing the need for enhanced surveillance, clinical management, and public health actions to mitigate the impact of Ceph-R NG. The plan includes objectives for state and local health departments, recommendations for clinicians and laboratorians, and strategies for monitoring effectiveness and expanding testing capacities. It stresses the urgency of developing alternative treatment options due to limited current therapies.

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Are Neisseria gonorrhoeae cephalosporin resistant?

CONCLUSION. Increase in N. gonorrhoeae isolates which are resistant to multiple antimicrobial agents including oral cephalosporins and the emergence of intermediate-level resistance to the injectable ephalosporins is now a serious problem.

How do you treat gonorrhea if you are allergic to cephalosporins?

In one clinical trial, dual treatment with single doses of IM gentamicin 240 mg plus oral azithromycin 2 g cured 100% of cases (lower one-sided 95% CI bound: 98.5%) and can be considered an alternative to ceftriaxone for persons with cephalosporin allergy (885).

How do you treat resistant Neisseria gonorrhoeae?

They recommend dual therapy as the primary treatment regimen, although considering local resistance data is crucial. Dual therapy options include ceftriaxone in combination with azithromycin and cefixime in combination with azithromycin.

What antibiotics are resistant to Neisseria gonorrhoeae?

gonorrhoeae now has shown its ability to also develop high-level resistance to ceftriaxone,29,30 which is the last remaining option for empirical first-line treatment of gonorrhea; this STI pathogen, therefore, seems to be evolving into a true superbug and, in the near future, may become untreatable in certain

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