AFR ii(M 2025

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The Atrial Flow Regulator (AFR) The AFR is a CE-marked EU Class III implantable, interatrial, shunting device dedicated to addressing shortcomings of atrial septostomy and improving overall safety and outcomes of interatrial shunting in patients with HFpEF or HFrEF.
A Stoichiometric AFR has the correct amount of air and fuel to produce a chemically complete combustion event. For gasoline engines, the stoichiometric, A/F ratio is 14.7:1, which means 14.7 parts of air to one part of fuel.
A normal result ranges from 0.94 to 1. Any number below that means you need some type of treatment because your blood flow is less than what it should be. For example, if your FFR is 0.75, your narrow section of the coronary artery is causing a 25% decrease in pressure.
It provides a unique therapeutic option for decompensated RV failure in end-stage PAH patients. Future applications of the AFR device may be extended to other heart failure populations like severe diastolic left ventricular dysfunction with increased left atrial pressure.
Major indications for Atrial Flow Regulator implantation. CHD, congenital heart disease; ECMO, extracorporeal membrane oxygenation; HF, heart failure; PAH, pulmonary artery hypertension.
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The atrial flow regulator (AFR) is an innovative technology to treat patients with symptomatic heart failure and increased left atrial pressure, particularly heart failure with preserved ejection fraction (HFpEF).

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