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It may be more appropriate to speak of a clinically meaningful effect size, which has been defined as the smallest difference (i.e., effect size) that patients perceive as beneficial and that would mandate, in the absence of troublesome side effects and cost, a change in the patients management.5 It seems
Simply stated, clinically important difference (CID) is the difference in outcome scores between 2 groups that can be considered clinically relevant. The notion of CID began as a way to assist in the interpretation of quality-of-life instruments and other patient-reported outcome measures (PROM).
The minimum clinically important difference (MCID) represents the smallest improvement considered worthwhile by a patient. The concept of an MCID is offered as the new standard for determining effectiveness of a given treatment and describing patient satisfaction in reference to that treatment.
The MCID is calculated based on the medium effect size: 0.3 effect size, where the effect size is a standardized measure of change obtained by dividing the difference in scores from baseline to posttreatment by the standard deviation of baseline scores. The MCID is 0.5 SD of the score.
Definitions and/or Common Applications. Minimal clinically important difference (MCID) The smallest difference that patients perceive as beneficial. In the absence of troublesome side effects or excessive cost, this difference would mandate a change in the patients management.
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The main difference between statistical and clinical significance is that the clinical significance observes dissimilarity between the two groups or the two treatment modalities, while statistical significance implies whether there is any mathematical significance to the carried analysis of the results or not.
Clinical significance is the measurement of practical importance based on research findings in patient care. In terms of treatment or intervention, clinical significance in research refers to the meaningful effect on patient healthcare outcomes.

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