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Specialists within Penn Neurology evaluate, diagnose and treat patients with neuromuscular conditions. As one of the oldest neuromuscular programs in the nation, we have pioneered many leading-edge diagnostic techniques and treatments available today.
Sensory-Motor Neuropathy Antibody Panel (Ganglioside) - The presence of antibodies to the gangliosides GM1, Asialo-GM1, GD1a and GD1b has been associated with motor and sensorimotor neuropathies.
The most common of these diseases is myasthenia gravis, an autoimmune disease where the immune system produces antibodies that attach themselves to the neuromuscular junction and prevent transmission of the nerve impulse to the muscle.
The Neuromuscular Laboratory provides sub-specialty laboratory services essential for the diagnosis of muscle and nerve diseases.
Some people have no disability. Others have partial or complete loss of movement, function, or feeling. Nerve pain may be uncomfortable and may last for a long time. In some cases, sensorimotor polyneuropathy causes severe, life-threatening symptoms.
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Basic screening tests for neuropathies should include a blood cell count, thyroid, renal and liver function tests, blood glucose levels, HbA1c, vitamin-B12, and immunofixation.
Motor Neuropathy Complete Antibody Panel - The panel includes ganglioside antibodies associated with motor neuropathies. Many of the anti-ganglioside antibodies associated with chronic immune neuropathies are monoclonal IgM antibodies. An evaluation for monoclonal gammopathy should be performed in this setting.
Idiopathic sensory-motor polyneuropathy is an illness where sensory and motor nerves of the peripheral nervous system are affected and no obvious underlying etiology is found. In many respects, the symptoms are very similar to diabetic polyneuropathy.
Electromyography (EMG) is a test to measure muscle response or electrical activity when a nerve in the muscle is stimulated. The EMG test is a diagnostic tool that helps a neurologist detect neuromuscular abnormalities.

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