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What happens if you stop taking ruxolitinib?

Upon cessation, ruxolitinib discontinuation syndrome develops in some patients. Clinical manifestations include rebound splenomegaly, cytopenias, acute respiratory distress syndrome, and systemic inflammatory response syndrome.

What is the half life of Ruxolitinib?

Ruxolitinib is metabolized primarily by CYP3A4, with a half-life of approximately 3 hours. Ruxolitinib is not removed by dialysis, although some active metabolites may be removed; therefore, the drug should be administered after dialysis.

Is Ruxolitinib teratogenic?

Ruxolitinib is a pregnancy category C teratogen. Although there is no evidence of teratogenicity, in animal studies, pregnant rats given this medication have shown approximately 9% reduction in foetal weight at the highest and maternally toxic dose of 60 mg/kg/day23.

What is the duration of action of ruxolitinib?

Ruxolitinib has a short terminal half-life of approximately 3 h for doses up to 100 mg [43], suggesting that twice-daily (b.i.d.) administration of ruxolitinib is preferable to once-daily dosing.

What is the pharmacokinetics of Ruxolitinib?

Ruxolitinib pharmacokinetics can be described with a two-compartment model and linear elimination. Volume of distribution differs between men and women, likely related to bodyweight differences. Metabolism is mainly hepatic via CYP3A4 and can be altered by CYP3A4 inducers and inhibitors.

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