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Is argatroban an antiplatelet?

Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.

What is the therapeutic category of argatroban monohydrate?

7.2 FDA Pharmacological Classification Argatroban is an Anti-coagulant and Direct Thrombin Inhibitor. The mechanism of action of argatroban is as a Thrombin Inhibitor.

What are the precautions for argatroban?

This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Avoid picking your nose.

What is the thrombin time monitoring of argatroban?

The recommended steady-state plasma argatroban concentration target is 0.51.0 g/ml, which corresponds to a thrombin time range of 80120 s (based on their thrombin time, performed using a final thrombin concentration of 1.25 u/ml).

Is argatroban a factor Xa inhibitor?

Argatroban is a synthetic monovalent direct thrombin inhibitor, the molecular structure of which contains an arginine residue. Argatroban is highly selective for thrombin and has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein).

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