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Methotrexate is usually the first medicine given for rheumatoid arthritis, often with another DMARD and a short course of steroids (corticosteroids) to relieve any pain.
NSAIDs are the most effective oral medicines for OA. They include ibuprofen (Motrin, Advil) naproxen (Aleve) and diclofenac (Voltaren, others). All work by blocking enzymes that cause pain and swelling. The problem is that some of those enzymes also help blood to clot and protect the lining of your stomach.
[6] Some commonly used NSAIDs include: aspirin (such as Disprin) ibuprofen (such as Nurofen) naproxen (such as Naprosyn) diclofenac (such as Voltaren) celecoxib (such as Celebrex). Uses[edit | edit source] NSAIDs are used to treat: Pain of rheumatoid arthritis (RA), osteoarthritis and tendonitis.
These drugs can slow the progression of rheumatoid arthritis and save the joints and other tissues from permanent damage. Common DMARDs include methotrexate (Trexall, Otrexup, others), leflunomide (Arava), hydroxychloroquine (Plaquenil) and sulfasalazine (Azulfidine).
NSAIDs include: Celecoxib (Celebrex) Diclofenac (Cataflam, Voltaren) Etodolac (Lodine) Ibuprofen (Advil, Motrin) Indomethacin (Indocin) Meloxicam (Mobic) Naproxen (Aleve, Naprosyn)

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The newest drugs for the treatment of rheumatoid arthritis are the Janus kinase (JAK) inhibitors, which are FDA approved under the brand names Rinvoq, Olumiant, and Xeljanz.
Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects.
Methotrexate is often the first drug prescribed for people newly diagnosed with rheumatoid arthritis.

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