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There are also other novel targets for diabetes mellitus control that could be exploited, such as GPCR 119 [13], GPER [14], 11-hydroxysteroid dehydrogenase 1 [15], Vaspin [16], Metrnl [17], PEDF [18], Fetuin-A [19], ACRP 30(AdipoQ) [20], Visfatin, Melatonin [21], GIP [22], GPCR [23].
Hyperglycemia is blood glucose greater than 125 mg/dL while fasting and greater than 180 mg/dL 2 hours postprandial. A patient has impaired glucose tolerance, or pre-diabetes, with a fasting plasma glucose of 100 mg/dL to 125 mg/dL.
Currently metformin is the first line drug for treatment of T2D. Emerging drug targets for T2D include AMPK, FBPase, GLP-1, GK, GPR-119, GSK-3, PTP1B, SGLT2, etc.
Medications for type 2 diabetes (antidiabetics) include: Metformin: This drug reduces the amount of glucose produced by the body, and has been used for a long time. Its the best studied diabetes medication, as well as one of the best tolerated. For this reason, doctors usually recommend trying metformin first.
To minimize this risk, many providers will recommend that individuals treated with insulin target a pre-meal blood sugar (plasma glucose) of 90-130 mg/dl and post meal blood sugar (plasma glucose) of less than 180 mg/dl.

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Type 2 diabetes, the most common type of diabetes, is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes mainly from the food you eat. Insulin, a hormone made by the pancreas, helps glucose get into your cells to be used for energy.
The NICE guideline for type 2 diabetes recommends that people are treated to an HbA1c target of 48 mmol/mol (6.5%), but less stringent targets may be appropriate for people who are older or frail, those who are unlikely to benefit from longer-term risk reduction e.g those with reduced life expectancy, those at high

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