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Today, many cancer patients take vitamins and other micronutrients (e.g., selenium, vitamin D) with the aim of improving their standard therapy or reducing the adverse effects of treatment and the underlying disease.
A meta-analysis of vitamin D supplementation on CRC survival outcomes also suggests clinically meaningful benefit (104). In patients with metastatic CRC, addition of high-dose vitamin D3 to chemotherapy resulted in statistically indocHub progression-free survival but improved supportive hazard ratio (90).
The best way to take vitamin C supplements is 2 - 3 times per day, with meals, depending on the dosage. Some studies suggest that adults should take 250 - 500 mg twice a day for any benefit. Talk to your doctor before taking more than 1,000 mg of vitamin C on a daily basis and before giving vitamin C to a child.
For adults, the tolerable upper intake level (UL) the highest daily intake likely to pose no risks is 2,000 mg per day. Vitamin C is water-soluble, so any excess is usually excreted in the urine rather than stored in the body.
Taking more than 2000 mg daily is possibly unsafe and may cause kidney stones and severe diarrhea. In people who have had a kidney stone, taking amounts greater than 1000 mg daily increases the risk of getting more kidney stones. When applied to the skin: Vitamin C is likely safe for most people.

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Signs and symptoms of cachexia and hypoalbuminemia are common in patients with advanced cancer. Deficiencies of vitamins B1, B2, and K and of niacin, folic acid, and thymine also may result from chemotherapy. Nutritional deficiencies are chemically correctable; however, the tumor must be eradicated to relieve cachexia.
Vitamin C has low toxicity and is not believed to cause serious adverse effects at high intakes [8]. The most common complaints are diarrhea, nausea, abdominal cramps, and other gastrointestinal disturbances due to the osmotic effect of unabsorbed vitamin C in the gastrointestinal tract [4,8].
It is not stored in large amounts in the body. Taking too much vitamin C is unlikely to cause harmful effects; however, taking vitamin supplements in mega doses (2,000 or 3,000 mg per day) can cause diarrhea, nausea, stomach cramps, vomiting, heartburn, headache and insomnia.

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