Lymph nodes and their locations - NHL Cyberfamily 2025

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The GI tract is the most frequently involved extranodal localization, accounting for 30-40% of extra-nodal lymphoma (10-12) and from 4-20% of all NHL cases (5,13). In Western countries, the most common localization is the stomach (approximately 50-60%), followed by the small (30%) and large intestine (around 10%).
Extranodal NHL may involve almost any organ in the body such as gastrointestinal tract, bone, brain, genitourinary organs, etc (2). F-FDG -PET/ CT is more effective than CECT in evaluating extra nodal lymphomatous infiltration.
Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes. The incidence of pENL is increasing and is probably due to better diagnostic immunophenotyping and imaging modalities.
The most common extralymphatic sites were the gastrointestinal tract, the head and neck region, and the lung.
The prognosis for PCNSL is poor, with a median survival of approximately 26 months [118] and the 5-year and 10-year survival rates of 35.2% and 27.5%, respectively [119]. Pathologically, more than 95% of PCNSL cases are diffuse large B cell lymphoma [120, 121].
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People who have extranodal NK/T-cell lymphoma, nasal type, usually develop a fast-growing lump inside their nose or in the sinuses (air-filled spaces) around the nose. You might have symptoms that affect your nose, eyes or face, such as: a blocked nose. nosebleeds, or nasal crusting.
The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin. The swelling is usually painless, although some people find that it aches.

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