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Peroxisome proliferator-activated receptor (PPAR) , /, and modulate lipid homeostasis. PPAR regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer.
What is the role of PPAR gamma in the liver?
Role of PPAR in the Liver PPAR is highly expressed in adipose tissue and macrophages, and plays important roles in adipogenesis, lipid metabolism, insulin sensitivity, and immune regulation [71].
What is the action of PPAR-gamma?
Activation of PPAR- causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-/ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function.
What is the mechanism of action of PPAR-gamma drugs?
MOA (Mechanism Of Action) The PPAR- receptors are a complex family of receptors found in the cell nucleus in muscle, fat, and liver. Among other roles, they regulate expression of genes responsible for lipid and protein metabolism, insulin signal transduction, and adipocyte and other tissue differentiation.
What is the role of hepatic peroxisome proliferator-activated receptor in NAFLD?
TZD-mediated activation of PPAR could serve as a good treatment for NAFLD because TZDs have shown anti-fibrogenic and anti-inflammatory effectsin vitro and increase insulin sensitivity in peripheral tissues which improves liver pathology.
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