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How does HCV affect cells?

Overall, there is strong evidence that HCV can bind and enter various cell types found outside the liver, and the process of infection can be studied in vitro [23]. B cells may preferentially bind free virus, while monocytes may preferentially bind virus-antibody complexes.

What is the HCV core protein?

The HCV core protein is a multifunctional protein, but with respect to the virus its main function is to form the viral capsid to surround and protect the genomic RNA while the virus passes from a cell to another [36].

What is the function of the HCV proteins?

HCV core protein is a highly conserved RNA-binding protein, which presumably forms the viral nucleocapsid and plays a role in pathogenesis [35]. E1 and E2 envelope glycoproteins are essential components of the HCV virion and necessary for viral entry and fusion [6, 7].

What are the glycoproteins in the envelope of HCV?

Hepatitis C virus (HCV) glycoproteins E1 and E2 form a heterodimer to constitute viral envelope proteins, which play an essential role in virus entry. E1 does not directly interact with host receptors, and its functions in viral entry are exerted mostly through its interaction with E2 that directly binds the receptors.

What does HCV do?

Hepatitis C is an inflammation of the liver caused by the hepatitis C virus. The virus can cause both acute and chronic hepatitis, ranging in severity from a mild illness to a serious, lifelong illness including liver cirrhosis and cancer.

What do HCV proteins do?

Expression of HCV proteins induces intracellular membrane alterations (the membranous web), which is the site of RNA replication. The nonstructural proteins NS3 to NS5B assemble in association with cellular factors to form a replication complex, which is responsible for RNA replication.

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